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Distinctive clinicopathological features of adenocarcinoma in situ and minimally invasive adenocarcinoma of the lung: A retrospective study

Lung Cancer Feb 27, 2019

Ishida H, et al. - In this review of patients with lung adenocarcinoma who had surgery between 2007 and 2014, researchers focused on distinguishing clinicopathological characteristics, in addition to histological invasiveness, in adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) of the lung. A significantly higher ratio of male to female patients was noted for those having MIA vs those with AIS. For MIAs vs AIS, significantly greater pathological tumor diameters and Ki-67 labeling index (LI) values were reported. An MIA was indicated by a Ki-67 LI of ≥2.8%. The presence of epidermal growth factor receptor (EGFR) mutations was more frequent in MIAs (33/69, 48%) vs AIS (9/34, 26%). A higher ratio of exon 19 deletions to exon 21 missense mutations was noted in MIAs vs in AIS. Although surgical outcomes for AIS and MIAs were similar, differences were observed in terms of gender, tumor diameters, computed tomography findings, Ki-67 LI and a subset of EGFR mutations, which validated the aptness of distinguishing the two subtypes.
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