Chianchiano P, et al. - Researchers here aimed to focus on distinction of intrahepatic metastasis from multicentric carcinogenesis in multifocal hepatocellular carcinoma using molecular alterations. Findings underscored the utility of molecular analyses to determine relatedness in multifocal hepatocellular carcinoma (HCC). However, targeted sequencing seemed helpful only in resolving this distinction in approximately 60% of patients.