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Distinction between rhinovirus-induced acute asthma and asthma-augmented influenza infection

Clinical & Experimental Allergy Apr 09, 2018

Guibas GV, et al. - Given that rhinovirus (RV) is an established trigger of asthma attacks, researchers hypothesized that influenza virus (IFV) infection may cause a condition essentially different from RV. In this cross-sectional study, they tested this hypothesis by assessing clinical features of RV/IFV-positive and -negative children, aged 6 months to 13 years, with respiratory symptoms and/or fever. Adjusted logistic regression models were used. Association of RV but not of IFV with wheeze and an asthma-like presentation was noted among children with respiratory symptoms and/or fever. A more generalised and severe disease possibly suggestive more of “asthma-augmented influenza” rather than an “asthma attack" was noted to be caused by IFV in those with an asthma history.
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