Ng MSN, Miaskowski C, Cooper B, et al. - As multiple concurrent symptoms are experienced by patients with end-stage renal disease receiving dialysis, researchers sought to recognize subgroups of patients based on their symptom experiences and the characteristics that distinguished among these subgroups. Further, they assessed outcomes linked with these subgroups. At two regional hospitals in Hong Kong, recruitment of a total of 354 patients on dialysis was done. Using a latent class analysis based on the occurrence ratings, they identified three latent classes: low (37.8%), moderate physical-low psychological (29.7%), and moderate physical-high psychological (32.5%). The low and moderate physical-low psychological classes could be distinguished by higher comorbidity burden and lower serum albumin levels. The highest number of symptoms, poorest quality of life outcomes, and more unscheduled clinic visits were reported in the moderate physical-high psychological class. Further, they identified a shorter mean survival time (421 vs 431 days). Consistent with findings in other chronic conditions, unique symptom experiences are recorded for subgroups of patients on dialysis, which justifies using an individualized approach to symptom management in these patients.