Bentsen SB, et al. - Whether distinct groups of COPD patients could be identified based on changes in the occurrence and severity of pain over 12 months, was investigated. Researchers also assessed if these groups differed on demographic, clinical, and pain characteristics, and health-related quality of life (HRQoL). Over 12 months, pain occurrence was reported by most of the patients, of those, 48% were in the “high probability of pain” group, while 29% were in the “moderate probability of pain” group. For the worst pain severity, 37% were in the “moderate pain” and 39% were in the “mild pain” groups. Higher pain interference scores, higher number of pain locations, and more respiratory symptoms were reported by patients in the higher pain groups. Few differences in HRQoL were found between the groups except for the symptom subscale. Overall, comprehensive pain management is warranted in COPD patients.