Jao J, Balmert LC, Sun S, et al. - The effect of untreated HIV infection as well as different antiretroviral therapy (ART) on the metabolome/lipidome was described.

• Researchers performed widely-targeted plasma metabolomic and lipidomic profiling on HIV-seronegative individuals and persons living with HIV (PLHIV) prior to and following the initiation ART [tenofovir/emtricitabine plus atazanavir/ritonavir (ATV/r) or darunavir/ritonavir (DRV/r) or raltegravir (RAL)].

• ART-naïve PLHIV showed increased lipogenesis relative to HIV-seronegative individuals.

• There was increased triaclyglycerols (TAGs) turnover for RAL vs ATV/r or DRV/r; this altered metabolome/lipidome after initiating ART linked with increased inflammation.