Crouch SH, et al. - Given the involvement of inflammatory mediators in the early stages of cardiovascular disease development, including hypertension, researchers compared a detailed range of 22 inflammatory mediators between young black and white adults, as well as, investigated the link with blood pressure. This study was performed on 1,197 adults (20–30 years; 50% black; 52% female) with detailed ambulatory blood pressures. Higher C-reactive protein, interferon-inducible T-cell alpha chemoattractant, macrophage inflammatory protein 3 alpha, but lower interferon-gamma, interleukin-1β, interleukin 8, interleukin 12, interleukin 17A, and tumour necrosis factor alpha was detected in black adults, for pro-inflammatory mediators. For anti-inflammatory mediators, lower levels (interleukin 5, interleukin 10 and interleukin 13) were consistently detected in the black group, leading to generally higher pro-to-anti-inflammatory ratios in black vs white adults. Overall, irrespective of blood pressure, gender or social class, black and white ethnic groups each consistently displayed unique inflammatory mediator patterns. In either of the groups, no link with blood pressure was identified.