Crouch SH, et al. - Given the implication of inflammatory mediators in the early stages of cardiovascular disease development, including hypertension, has been reported, and a higher prevalence of hypertension in black vs white populations has been indicated by global reports, researchers hypothesized the involvement of specific inflammatory mediators, and performed comparisons between young black and white adults for a detailed range of 22 inflammatory mediators, and explored the link with blood pressure. Higher C-reactive protein, interferon-inducible T-cell alpha chemoattractant, macrophage inflammatory protein 3 alpha, but lower interferon-gamma, interleukin (IL)-1β, IL-8, IL-12, IL-17A, and tumour necrosis factor alpha were found in black adults, for pro-inflammatory mediators. Lower levels (IL-5, IL-10 and IL-13) were identified consistently in the black group, for anti-inflammatory mediators, and this led to generally higher pro-to-anti-inflammatory ratios in black vs white adults. In this study, irrespective of blood pressure, gender or social class, a consistent presentation with unique inflammatory mediator patterns was evident in black and white ethnic groups. In either of the groups, no link with blood pressure was identified.