Murakami T, et al. - An exploratory analysis was performed of the histopathological features in colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp (SSA/P) and conventional tubular adenoma. A higher potential for lymphatic invasion and lymph node metastasis was discovered in the submucosal invasive carcinomas with SSA/P (CA-SSA/P) lesions. They illustrated distinct histopathological features, including mucinous component, serrated architecture, tumour-infiltrating lymphocytes, Crohn-like inflammatory reaction, and absence of desmoplastic reaction, compared to their conventional counterparts.