Brown HJ, Ganti A, Gattuso P, et al. - This study was intended to determine distinct histopathologic features of complicated sinusitis. Researchers used a structured histopathology report to examine sinus tissue extracted during functional endoscopic sinus surgery. They compared a total of 13 histopathology variables between patients with complicated sinusitis (CS), CRS without nasal polyps (CRSsNP), and CRS with nasal polyps (CRSwNP). The study found significant histopathological differences in patients with CS, CRSsNP, and CRSwNP. According to the findings, CS patients did not perfectly fit either a CRSsNP or CRSwNP profile, underscoring the importance of delineating the histopathological features of CS. This research gives insight into the histologic aspects of CS, providing initial evidence that it is an aggressive neutrophilic inflammatory process.