Dorgham K, Quentric P, Gökkaya M, et al. - Since markedly elevated levels of pro-inflammatory cytokines and defective type-I interferon responses were reported in COVID-19 patients, researchers sought to determine if particular cytokine profiles are correlated with COVID-19 severity and mortality. At hospital admission, cytokine concentrations and SARS-CoV-2 antigen were measured in the serum of 115 symptomatic COVID-19 patients, who were divided into three respiratory severity groups: no need for mechanical ventilatory support, intermediate severity requiring mechanical ventilatory support and critical severity requiring extracorporeal membrane oxygenation. Different cytokine profiles are associated with COVID-19 severity and are predictive of mortality differently depending on oxygen support modalities. Such findings support the use of cytokine profiling in the treatment of COVID-19 patients.