Abbas EE, Li C, Xie A, et al. - Researchers conducted this comparative cross‐sectional study to examine the clinical, hematological, and histopathological changes in chronic rhinosinusitis with nasal polyps (CRSwNP) endotypes and its association with microbiota. The sample consisted of 46 patients with CRSwNP (34.69 ± 16.39 years old) who had endoscopic sinus surgery and subdivided into eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP and NECRSwNP) groups based on eosinophilic tissue inflammation. They also included 12 healthy controls. Compared with NECRSwNP, ECRSwNP displayed a statistically significant rise in the computed tomography score, endoscopic score, blood eosinophil percentage, tissue eosinophil count, inflammation degree, subepithelial edema, and eosinophil aggregation. In the ECRSwNP group, the abundance of Moraxella and Parvimonas was significantly higher. Distinct microbiota dysbiosis in CRSwNP endotypes was found to be associated with various clinical pathologies. In patients with ECRSwNP and NECRSwNP, significant clinical pathology and microbiota changes were evident. Understanding such variations will improve the prognosis and treatment of chronic rhinosinusitis.