Distinct characteristics of VEGF‐D and VEGF‐C to predict mortality in patients with suspected or known coronary artery disease
Journal of the American Heart Association Apr 27, 2020
Wada H, Suzuki M, Matsuda M, et al. - Given VEGF‐D (vascular endothelial growth factor D) and VEGF‐C represent secreted glycoproteins that are capable of triggering lymphangiogenesis and angiogenesis, and an inverse and independent link of serum VEGF‐C level with all‐cause mortality has been recently shown in patients with suspected or known coronary artery disease, so, researchers undertook this multicenter, prospective cohort analysis to determine if VEGF‐D had distinct links with death and cardiovascular events in those patients. This study involved 2,418 patients with suspected or known coronary artery disease undergoing elective coronary angiography. In this study, the VEGF‐D level was identified to be significantly related to all‐cause mortality as well as cardiovascular death but not with major adverse cardiovascular events, following adjustment for likely clinical confounders, cardiovascular biomarkers (N‐terminal pro‐B‐type natriuretic peptide, cardiac troponin‐I, and high‐sensitivity C‐reactive protein), and VEGF‐C. In this analysis, a high VEGF‐D value appeared to independently predict all‐cause death among these patients.
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