Distinct asthma phenotypes with low maximal attainment of lung function on cluster analysis
Journal of Asthma Oct 19, 2019
Bhargava S, Holla AD, Jayaraj BS, et al. - Researchers used a cluster analysis approach to characterize clinical phenotypes of asthma in an Indian cohort including patients with confirmed asthma (N = 100) who had at least 6-months of follow-up data available. These patients were selected via retrospective chart review. Four distinct clinical phenotypes of asthma were discovered via cluster analysis in an Indian cohort of well-characterized patients with asthma. Poor attainment of maximum lung functions was reported in two of these four phenotypes. Cluster 1 included 40 patients and was characterized by childhood onset of disease, normal body weight, equal gender distribution and attainment of normal lung function. Cluster 2 included 16 patients and showed the following features: adolescent disease-onset, being obese, majority were males and had poor attainment of maximum lung functions. Including 20 patients, Cluster 3 was characterized by older age, late-onset of disease, obese, majority male and had poor attainment of maximum lung function. The patients in Cluster 4 (N = 24) had adult-onset of disease, were obese, predominantly female and achieved normal lung function.
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