Kappelmann N, Arloth J, Georgakis MK, et al. - In this genetic correlation and 2-sample mendelian randomization (MR) study, researchers examined the genetic overlap and correlations between inflammatory activity, metabolic dysregulation, and individual depressive symptoms. Coheritability between C-reactive protein levels and individual depressive symptoms is reported in this study, which may result from the possible causal relationship of metabolic dysregulation with anhedonia, tiredness, appetite changes, and feelings of inadequacy. The study also revealed that suicidality is associated with interleukin 6 (IL-6) signaling. Such results may have clinical impacts, underscoring the possibility of a strategy for suicide prevention with anti-inflammatory approaches, particularly IL-6 blockade.