Zhang Y, Zhu Y, Pei Y, et al. - Researchers examined a cohort of chronic low back-related leg pain (cLBLP) patients (n = 25) and well-matched healthy controls (n = 27) for the alteration of homotopic connectivity. Further, they investigated how this alteration is clinically associated with the cLBLP patients. The participants were made to undergo MRI scanning and were offered a battery of clinical tests. Using the voxel-mirrored homotopic connectivity (VMHC), they analyzed the interhemispheric coordination in the typical (0.01–0.1 Hz) as well as five specific (slow-6 to slow-2) frequency bands. In the typical and five specific frequency bands, they observed significant positive relationships between the VMHC values of medial prefrontal cortex and the visual analogue scale scores, while there appeared negative correlation between the VMHC values of basal ganglia and the values of two-point tactile discrimination test for the right hand in cLBLP patients, etc. Results suggest the possible involvement of multiscale frequency-related interhemispheric disconnectivity in the central pathogenesis of functional coordination in patients with cLBLP.