Shahu A, Herrin J, Dhruva SS, et al. - As higher blood pressure and worse cardiovascular outcomes have been reported in communities of low socioeconomic status in observational studies, researchers focused on the impact of socioeconomic context, defined as the county-level median household income, on clinical outcomes of antihypertensive therapy, including blood pressure control and cardiovascular outcomes, using data from ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). A standard protocol was used to treat participants in ALLHAT. They found poorer blood pressure control and worse outcomes for some adverse cardiovascular events among ALLHAT participants in the lowest-income sites, despite standardized treatment protocols. This highlights the significance of measuring and addressing socioeconomic context.