Liu Z, et al. - Researchers focused on the disparities in cancer incidence among Chinese people living in urban Shanghai, Hong Kong, Taiwan, Macau, Singapore and Los Angeles. Either the Cancer Incidence in Five Continents plus database or the regional cancer registry was used to obtain cancer case data and population data. By applying a rate model, they assessed regional discrepancies in cancer risk with Shanghai was set to be the reference. Compared with other five populations, a significantly higher incidence of stomach, liver, esophageal, pancreatic, and brain and central nervous system (CNS) cancers, as well as lower incidence of colon, prostate, breast, cervical, oral cavity and pharynx cancers, was reported in Shanghai. Across Chinese populations sharing a similar genetic background but living in different regions, distinct cancer profile was observed, which was indicative of a major role of environmental factors in determining cancer development and justify implementation of region-tailored cancer prevention strategies.