Parekh HD, et al. - In this IRB approved study cohort comprising colorectal cancer (CRC) patients diagnosed at < 50 years of age (UF institutional registry 2000-2017), researchers studied the disease characteristics and treatment outcomes in this young patient population. A total of 286 patients were diagnosed at a median age of 45 years with 212 (74%) diagnosed between age 40-50. Rectal primary was detected in one third (35.7%) of patients. Adenocarcinoma (ACa, 84.6%) was identified as most common histology. The poorly differentiated tumor was seen among 20% of those. An advanced primary (T3/T4, 65%) was seen in more than half of patients, with 44% having lymph node positive disease. Low alb levels ≤ 34 g/l, advanced primary tumor (T3/T4), nodal disease (N1/N2) and presence of diffuse metastasis were found to be related to poor survival. Aggressive management was more likely to be employed in younger CRC patients. Perioperative therapy was administered to a higher proportion of early stage patients. Even with similar prognostic factors, advanced stage disease could have an improved cancer-specific survival.