Nemmi F, et al. - In order to evaluate the adverse effects of neurofibromatosis Type 1 on the brain (on both gray and white matter), investigators conducted a multicentric cross-sectional study, which involved 42 typically developing and 38 neurofibromatosis-1 children to a multimodal MRI evaluation including T1, diffusion-weighted and resting state functional sequences. Among these two groups, structural indices could be able to discriminate with the mean diffusivity heading to performance as high as the combination of all structural indexes combined, whereas bad performances were shown by the functional indices.