Hirasawa K, Smith CA, West ME, et al. - In this cross-sectional study, researchers identified characteristics of patients with early open-angle glaucoma showing greater macular perfusion density loss compared with macular ganglion cell layer thickness loss. In patients and healthy control individuals, optical coherence tomography imaging of the optic nerve head and macula was conducted. Data from 89 patients (median mean deviation with the 24-2 and 10-2 tests, Humphrey Field Analyzer: -1.96 dB and -1.49 dB, respectively) and 54 controls have been analyzed. Compared with conventional structural loss in the macula, less than one-third of patients with early glaucoma had more loss of perfusion. Findings suggested that even within a range of high-quality images, lower signal strength can be at least partially responsible for apparent perfusion loss.