Ling HZ, Xu SZ, Leng RX, et al. - Researchers analyzed sera from 15 SLE people and five healthy volunteers by utilizing human proteome microarrays to recognize candidate SLE-related autoantibodies in order to systematically investigate new autoantibodies that might be good biomarkers for use in SLE diagnosis. A total of 31, 11 and 18 autoantibodies were recognized to be expressed at notably higher levels in the SLE group in comparison with the healthy volunteers, disease controls and healthy volunteers plus disease control groups, respectively, with 25, 7 and 13 of these variably expressed autoantibodies being priorly unreported. It was found that the combined autoantibody panels recognized here display promise for the diagnosis of SLE and for differential diagnosis of different major rheumatic immune diseases.