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Discontinuation of intraoperative liposomal bupivacaine in primary THA does not clinically change postoperative subjective pain, opioid consumption or objective functional status

Journal of Arthroplasty Feb 02, 2021

Feng JE, Ikwuazom CP, Slover JD, et al. - This study was attempted to evaluate the impact of discontinuing intraoperative liposomal bupivacaine (LB) periarticular injection (PAI) on immediate postoperative subjective pain, opioid consumption, and objective functional outcomes. In the analysis, opiate administration events were converted into Morphine Milligram Equivalences per patient per 24-hour interval. The validated Activity Measure for Post-Acute Care (AM-PAC) tool was applied to assess functional results. For this analysis, 638 primary total hip arthroplasties received LB followed by 939 that did not. This study’s findings reveal that a small statistical, but not clinically meaningful, variation was found in subjective pain scores with LB PAI discontinuation. After LB PAI discontinuation, opioid consumption and postoperative AM-PAC functional scores were unchanged.

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