Downing KF, Oster ME, Klewer SE, et al. - Disabilities may be experienced by two of 5 adults suffering from congenital heart defects (CHD), and presence of disabilities results in impaired health‐related quality of life (HRQOL) in such patients.

• Analysis of the 2016–2019 CH STRONG (Congenital Heart Survey to Recognize Outcomes, Needs, and Well‐Being) population‐based sample of 19‐ to 38‐year‐olds with CHD from 3 US locations.

• Among participants (n=1,478), disabilities were experienced by 40%, and most prevalent (29%) was cognition.

• A 5 to 8 times higher prevalence of disability types was reported in adults with CHD vs the general population.

• Greater odds of being female, and of having non‐Hispanic Black maternal race and ethnicity, severe CHD, recent cardiac care, and noncardiac congenital anomalies were present in those with ≥1 disability.

• Impaired mental HRQOL was evident, on average, in adults with CHD and cognition, mobility, and self‐care disabilities, and impaired physical HRQOL was seen in those with any disability type.