Rasmussen EB, Eriksen LL, Greisen SR, et al. - In this prospective cohort study, researchers sought to investigate connections between non-classical monocyte subsets and cell surface markers of migration with disease activity in patients with severe alcoholic hepatitis (AH). Samples from two AH patient cohorts were examined. Cohort 1 consisted of 15 AH patients who were followed for 30 days and 8 healthy controls (HCs), while cohort 2 consisted of 23 AH patients who were followed for 90 days and 9 HCs. In both cohorts, circulating non-classical monocytes in all but absent in patients with AH compared with HC. In this investigation, the authors describe an almost complete depletion of circulating non-classical monocytes in the blood in two independent cohorts of patients with AH, which may be linked to the possible harmful recruitment of these cells to the liver. Such findings contribute to a better understanding of the disease, which may lead to therapies that target the acute inflammatory response that causes severe AH.