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Digoxin use in infants with single ventricle physiology: Secondary analysis of the Pediatric Heart Network Infant Single Ventricle trial public use dataset

Pediatric Cardiology Aug 18, 2018

Truong DT, et al. - Researchers conducted a post-hoc analysis of the Pediatric Heart Network Infant Single Ventricle public use dataset to discover how digoxin correlates with survival and change in weight-for-age Z-score (WAZ) prior to superior cavopulmonary connection (SCPC) surgery and at 14 months in a heterogeneous group of single ventricle infants. Findings suggested no association of digoxin with improved survival during the interstage or at 14 months in a mixed single ventricle cohort, however, there was a trend towards improved interstage transplant-free survival in post-Norwood infants. It was noted that digoxin was related to poorer weight gain.

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