Musio D, et al. - In this work, researchers aimed to assess the optimal radiotherapy schedule for the treatment of painful bone metastases and verify if could cause different biological effects on bone. After radiotherapy, the Apparent Diffusion Coefficient values increased correspondingly with increased cell death. Despite an equal pain control, Multiple Fractions Radiation Therapy (MFRT) treatment appeared more effective to achieve cancer cells kill. The preliminary data seemed explaining the higher retreatment rates in Single Fraction Radiation Therapy vs MFRT in long survivors.