Wiegertjes K, Dinsmore L, Drever J, et al. - Experts aspired to explore whether the presence of diffusion-weighted imaging-positive (DWI+) lesions is correlated with recurrent stroke after intracerebral haemorrhage (ICH). The REstart or STop Antithrombotics Randomised Trial (RESTART) evaluated the impact of restarting vs avoiding antiplatelet therapy after ICH on major vascular events for up to 5 years. Of 537 candidates in RESTART, 247 (median (IQR) age 75.7 (69.6–81.1) years; 170 men (68.8%); 120 started vs 127 avoided antiplatelet therapy) had DWI sequences on brain MRI at a median of 57 days after ICH, of whom 73 (30%) had one or more DWI+ lesion. Eighteen participants had recurrent ICH and 21 had an ischaemic stroke during a median follow-up of 2 years (1–3). Findings suggested an association of DWI+ lesion presence in ICH survivors with recurrent ICH, but not with ischaemic stroke. There was no evidence that the presence of a DWI+ lesion altered the effects of antiplatelet therapy on recurrent stroke after ICH. Such findings shed new light on the significance of DWI+ lesions, which may be indicators of microvascular mechanisms linked to recurrent ICH.