Kim JY, et al. - Whether quantitative diffusion metrics derived from diffusion tensor imaging (DTI) were correlated with histological prognostic factors in breast cancer subjects was investigated in this retrospective study. Two hundred fifty-one consecutive women with breast cancer who underwent preoperative magnetic resonance (MR) imaging with DTI were identified between 2016 and 2017. It was revealed that mean diffusivity (MD) and fractional anisotropy (FA) were significantly lower for breast cancers than for normal breast tissues. Findings revealed that DTI-derived diffusion metrics, like MD and FA, were correlated with histological prognostic factors in breast cancer patients. Multivariate linear analysis showed that both larger size (>2 cm) and high histological grade (grade 3) were significantly associated with lower MD and FA in invasive breast cancer patients.