Duarte A, et al. - In this investigation, researchers validated a radial imaging spin-echo diffusion tensor (RAISED) sequence of 3 T articular cartilage for high-resolution diffusion tensor imaging (DTI). The implementation of the RAISED sequence is described, including the algorithm used for non-linear motion correction. For this analysis, DTI has been acquired in asymptomatic subjects (n = 6) with dubious subjects (Kellgren-Lawrence [KL] grade 1, n = 9) and mild (KL = 2, n = 9) with symptomatic knee osteoarthritis (OA). Investigators found that the root mean squared coefficient of variation of the global test-restest reproducibility was 3.54% for mean diffusivity (MD) and 5.34% for fractional anisotropy (FA). According to findings, the RAISED sequence with the proposed reconstruction framework gives a reproducible in vivo evaluation of DTI parameters at 3 T and possibly the early stages of the disease in large regions of interest. RAISED-based measurement of articular cartilage DTI with non-linear motion correction can distinguish healthy from OA subjects.