Zhao Q, Xie T, Fu C, et al. - Researchers undertaken to assess whether whole-lesion histogram and texture analysis using apparent diffusion coefficient can discriminate between idiopathic granulomatous mastitis (IGM) and invasive breast carcinoma (IBC), both of which appeared as non-mass enhancement lesions without rim-enhanced masses. In this retrospective study, they recruited a sum of 58 pathology-proven female individuals at two independent study sites (27 IGM patients and 31 IBC patients). They performed diffusion-weighted imaging (3b values, 50, 400 or 500, and 800 s/mm 2) using 1.5 T or 3 T MR scanners from the same vendor. They conducted Univariate analysis and multivariate logistic regression analysis to distinguish significant variables for differentiating IGM from IBC. They measured the receiver operating characteristic curve. They also reported interobserver reliability between two observers for the histogram and texture measurement. The outcomes indicated that whole-lesion histogram and texture analysis using apparent diffusion coefficient gives a non-invasive analytical method to the differentiation between IGM and IBC, both showing with non-mass enhancement without rim-enhanced masses.