Delli Colli L, Gabrielli S, Abrams EM, et al. - In the present study, the researchers sought to assess children presenting with suspected serum sickness–like reactions (SSLRs) through a graded oral challenge (GOC). All children referred to the Montreal Children's Hospital for potential antibiotic allergy (β-lactam or other antibiotics) and a clinical presentation compatible with SSLR have been selected for the study between March 2013 and February 2020. Of the 75 patients with suspected SSLRs, the median age was 2.0 years and 46.7% were males. This is the first and largest pediatric study evaluating SSLR using a GOC. The results indicate that the use of GOC is safe and sufficient for the distinction between β-lactam-induced SSLR and viral exanthem in this population.