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Differentiating axillary lymph node metastasis in invasive breast cancer patients: A comparison of radiomic signatures from multiparametric breast MR sequences

Journal of Magnetic Resonance Imaging Mar 15, 2019

Chai R, et al. - In this retrospective study involving 120 breast cancer patients, researchers evaluated the impact of ascertaining axillary lymph node (ALN) metastasis by breast MRI-derived radiomic signatures and assessed the discerning abilities of different MR sequences. Via the Mann–Whitney U-test, Fisher's exact test, least absolute shrinkage selection operator (LASSO) regression, and receiver operating characteristic analysis, they found the accuracy/AUC of the four sequences was 79%/0.87, 77%/0.85, 74%/0.79, and 79%/0.85 for the T1WI, second postcontrast phase (CE2), T2WI, and DWI, respectively. Findings suggested a relationship between breast tumor's radiomic signatures from preoperative breast MRI sequences with the ALN metastasis status, where CE2 phase and the contrast enhancement kinetic features result in the highest classification effect.

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