Wang X, et al. - A sum of 85 candidates were analyzed to examine the predictive advantage of histological parameters and molecular markers for neoadjuvant hormonal therapy (NHT) in prostate cancer (PCa). They observed 73% of tumors associated with drug-sensitive (DS) group and the rest 27% were drug-resistant (DR). They recorded 4 pathological variables ie, cribriform growth pattern, macronucleoli, ductal adenocarcinoma differentiation, and PTEN loss in needle biopsies were significantly correlated with DR effect. They signified macronucleoli, ductal adenocarcinoma differentiation, and PTEN loss expression as predictive factors for predicting the DR effect. They preferred combined pathological indicators in predicting DR response better as compared to that of model based on individual factor alone.