Seng JJB, Kwan YH, Lee VSY, et al. - In the present study, the researchers sought to segment type 2 diabetes mellitus (T2DM) patients into distinct classes and assess their differential healthcare use, diabetes-related complications, and mortality patterns. Latent class analysis was performed on a retrospective cohort of 71,125 T2DM individuals. According to results, five classes of T2DM patients have been identified. Depression prevalence was high among patients in class 3 (younger females with short-to-moderate T2DM duration and high psychiatric and neurological disease burden) and class 5 (older patients with moderate-to-long T2DM duration and high disease burden with end-organ complications). Class 5 patients faced the greatest risk of myocardial infarction, end-stage renal disease requiring dialysis initiation, stroke, lower-extremity amputation, and mortality. Findings suggested that T2DM individuals can be segmented into classes with differential healthcare use and outcomes. Screening of the depression should be considered for the two patient classes identified.