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Differential expression of osteopontin, and osteoprotegerin mRNA in epicardial adipose tissue between patients with severe coronary artery disease and aortic valvular stenosis: Association with HDL subclasses

Lipids in Health and Disease Aug 24, 2017

Luna–Luna M, et al. – The researchers explored the differential expression of osteonectin (ON) and osteoprotegerin (OPG) mRNA in epicardial adipose tissue (EAT) between patients with severe coronary artery disease (CAD) and aortic valvular stenosis. Their findings showed that osteopontin (OPN), ON, and OPG genes were transcribed in EAT. Except for ON, the level of expression was different in CAD patients and control group, and correlated with some high–density lipoprotein (HDL) subclasses, indicating a new role of these lipoproteins.
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