Kotb IS, et al. - Experts quantified the effects of 3 commonly used psoriasis treatment modalities on the T helper (Th)1, Th2, Th17 and Treg subsets, and tested if any change correlated with clinical response in patients with psoriasis. Findings suggested that to optimize or design therapeutic strategies to overcome the inflammatory drivers more effectively and restore the Th17–Treg balance in psoriasis the differential impacts reported here for the above-mentioned treatment modalities could be exploited. Clinical response to the treatments was seen in all patients. The numbers of circulating and skin Tregs was significantly increased by narrowband ultraviolet B (NB-UVB), while, by contrast, adalimumab reduced Th17 cells in these compartments, and Dovobet had dual effects by both increasing Tregs and reducing Th17 cells.