Lui SSY, Yip SSL, Wang Y, et al. - Researchers intended to determine if there is an association between neurological soft signs (NSS) and treatment resistance in first-episode schizophrenia patients. The sample consisted of 52 first-episode schizophrenia patients, who were evaluated at baseline, the sixth month, and the fifth year using the abridged version of the Cambridge Neurological Inventory. The results obtained from the longitudinal study confirm the potential utility of NSS in identifying treatment resistance in first-episode schizophrenia. Progressive worsening of NSS in patients with treatment-resistant schizophrenia may reflect the development of underlying neuropathology. More research with large samples of treatment-resistant schizophrenia patients is required.