Chen Q, et al. – An inquiry was pursued of the association between the expression patterns of plasma T–helper cell (Th) 1, Th2, Th17, and Th22–related cytokines with the serum autoreactivity and the allergen sensitivity in chronic spontaneous urticaria (CSU). A more significant Th2 immune response was elicited by acute urticaria than CSU. A link was illustrated between varied expression patterns of plasma Th1–, Th2–, Th17–, and Th22–related cytokines and serum autoreactivity or allergen sensitivity in CSU. The analysis JAK–STAT pathway in the pathogenesis of CSU necessitated additional trials.