Chen X, Qian W, Weng X, et al. - This study was carried out to ascertain the optimal threshold of plasma Fbg and D-dimer in the diagnosis of periprosthetic joint infection (PJI) and compare their diagnostic value to that of C-reactive protein (CRP) and ESR and explored whether Fibrinogen (Fbg) and D-dimer perform differently than CRP and ESR as diagnostic indicators for different types of PJI. Researchers identified a sum of 115 revision cases after total hip arthroplasty and total knee arthroplasty. Based on demographic characteristics, propensity score matching was used to match 25 culture-positive cases with 50 culture-negative cases. Compared to CRP and ESR, plasma Fbg exhibited similar diagnostic performance in predicting culture-positive results in PJI. It was shown that plasma D-dimer showed high specificity but low sensitivity. As per the results, Fbg and D-dimer did not exhibit better diagnostic performance with different pathogens and different types of PJI. There is a need for future trials to evaluate the difference between serum D-dimer and plasma D-dimer in the arthroplasty population.