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Different alterations of glomerular filtration rate and their association with uric acid in children and adolescents with type 1 diabetes or with overweight/obesity

Pediatric Diabetes Apr 01, 2020

Santucci MP, Muzzio ML, Peredo MS, et al. - Researchers undertook this cross‐sectional analysis to compare the prevalence of glomerular filtration rate (GFR) changes as well as its link with uric acid among children and adolescents suffering from type 1 diabetes (T1D) vs overweight (OW)/obesity (OB). Participants included 29 youths (aged: 13 ± 2 years) with T1D (disease duration: 7 ± 3 years) and 165 with OW/OB (aged: 11 ± 3 years). The cases with an albumin‐creatinine ratio > 3.39 mg/mmol were eliminated from this study. Children with T1D vs OW/OB were found to have a higher hyperfiltration. A 10% of low GFR was demonstrated by children with OW/OB. According to the findings, GFR changes were identified to be different between youths with T1D and with OW/OB. In OW/OB children, lower GFR values were reported in relation to higher uric acid, older age, and puberty.

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