Sabaté-Llobera A, et al. - In this retrospective study, researchers assessed the metabolic behavior of cholangiocarcinoma in PET/CT according to its location (intra or extrahepatic) and examined the association between metabolic parameters of the primary tumor and tumor markers (CA19-9 and CEA), determining their prognostic significance. This retrospective study included PET/CT of 60 patients with untreated cholangiocarcinoma, divided into two groups based on tumor location. Findings revealed that intra and extrahepatic cholangiocarcinomas behave differently on PET/CT. No differences between both groups exist in its capacity to detect regional or distant disease. Results of this study suggested that metabolic parameters and levels of tumor markers appear to correlate with tumor burden, impacting in prognosis.