Differences of recovery from rocuronium-induced deep paralysis in response to small doses of sugammadex between elderly and nonelderly patients
Anesthesiology Oct 20, 2018
Muramatsu T, et al. - Considering the delay in complete recovery from rocuronium-induced muscle paralysis with sugammadex in elderly patients, researchers investigated the rate of recovery from deep neuromuscular block with low-dose sugammadex and the incidence of recurarization in elderly vs non-elderly patients. In anesthetized elderly and nonelderly patients under deep paralysis with rocuronium, they measured a change of train-of-four ratio per minute (primary outcome variable) with an acceleromyograph neuromuscular monitor during spontaneous recovery from rocuronium-induced muscle paralysis (0.6 mg/kg) and after infusion of low-dose sugammadex (50 µg · kg-1 · min-1). The negative change of train-of-four ratio defined the recurarization. Outcomes revealed a higher risk for recurarization and residual muscle paralysis for elderly patients when low-dose sugammadex is administered.
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