Gama R, et al. - In this case-control study, researchers contrasted the optic disks of children and adults with megalopapilla utilizing optical coherence tomography (OCT). The sample consisted of individuals with megalopapilla and normal sized disks seen between February 2013 and July 2015 at the Hospital da Luz, Lisbon. All individuals and controls were imaged with spectral domain OCT, and optic nerve head parameters were assessed. Rim area, cup:disk ratio, and cup volume were the main outcome measures. In total, 168 eyes of 168 individuals [78 with megalopapilla and 90 with normal-sized disks] were involved. Children (with megalopapilla or normal-sized disks) had a larger rim area and a smaller cup compared with adults with the same disk size. Such results indicate the optic disk cup enlargement and the rim area reduction may occur during life.