Akhbari P, Jaggard MK, Boulangé CL, et al. - Twenty-four synovial fluid (SF) samples (12 hip, 12 knee) were obtained from individuals with end-stage osteoarthritis (ESOA) who underwent hip/knee arthroplasty in order to recognize variations in osteoarthritic hip and knee SF metabolites using metabolic profiling with Nuclear MR (NMR) spectroscopy. Notable variations in the metabolic profile among the groups were seen. In the knee group vs the hip group (N-acetylated molecules, glycosaminoglycans, citrate, and glutamine), four metabolites were detected in significantly greater quantities. This was the first study to designate variations in the metabolic profile of hip and knee SF in ESOA. In conclusion, the recognized metabolites can broadly be classified into those included in collagen degradation, the tricarboxylic acid cycle and oxidative metabolism in diseased joints. Moreover, these findings might signify an intra and extra-articular factors combination.