García-Solano J, et al. - In view of the fact that histological subtypes of colorectal carcinomas (CRCs) resulting from the serrated route, such as serrated adenocarcinoma (SAC) and CRC showing histological and molecular characteristics of microsatellite instability (hmMSI-H), share common characteristics (female gender, right-sided location, mucinous histology and altered CpG methylation) but differ dramatically in terms of prognosis, immune response development and treatment options, researchers conducted expression profiling comparison for finding out functions and molecules responsible for such differences. This comparison resulted in an over-representation of innate immunity functions and ICAM1 was more expressed in hmMSI-H while two genes (CRCP and CXCL14) were more expressed in SAC. Subsequently, these array outcomes validated by qPCR, and CXCL14 and ICAM1 by immunohistochemistry. The findings were confirmed by information obtained from public databanks. The study findings highlight specific functions and genes that provide a better understanding of the role of the immune response in the serrated pathological route and can help identify molecules that can be actionable.