Sun T, et al. - Investigators analyzed the outcomes of maternal metabolomic profiles variation between spontaneous pregnancies and pregnancies conceived with fertility treatments. They observed significant metabolic variations the lipid superpathway viz, steroid metabolites, lipids with docosahexaenoyl acyl chains, acyl cholines, and xanthine and benzoate metabolites among the spontaneous and 2 infertility groups. Significant elevation of 17-β-estradiol and progesterone levels in the infertility groups, with greatest differences between the spontaneous and IVF groups, were also noted. They concluded adverse outcomes linked to infertility and the treatments used because of greater levels of steroids and their metabolites due to increased hormone production from placenta reprogrammed from fertility treatments.