Choi YJ, et al. - Researchers used cytokines from polypous tissues and assessed the pathogenesis specific to local allergic rhinitis (LAR) vs allergic rhinitis (AR) and nonallergic rhinitis (NAR) in this study involving 43 patients with AR (n = 15; mean age, 17.4 years), LAR (n = 12; mean age, 15.9 years), and NAR (n = 16; mean age, 15.6 years) who underwent polypectomy. Patients were assessed for atopic status and for the levels of regulated on activation of normal T cell expressed and secreted (RANTES), tumor necrosis factor (TNF) alpha, interleukin (IL) 5, and sera to assess total immunoglobulin E (IgE) and eosinophil cationic protein by using immunoassays. Based on the findings, a possible important role of RANTES as well as its contribution to allergic reaction in LAR was suggested. Data pointed to its possible association with the pathogenesis of LAR.