Chen Z, et al. - In a population of 174 patients with end-stage renal disease (ESRD) (median age: 57 years, 63% male), researchers examined the sex-specific associations of coronary artery calcification (CAC) score with total body BMD (tBMD) and BMD of different skeletal sub-regions. Assessments of BMD (measured by dual-energy X-ray absorptiometry), CAC score (measured by cardiac computed tomography), and circulating inflammatory biomarkers were carried out. CAC > 100 AUs was detected in 104 patients; these patinets were older, had higher prevalence of both clinical cardiovascular disease (CVD) and diabetes, higher level of high sensitivity C-reactive protein, tumor necrosis factor, interleukin-6, and lower T-score of tBMD. Findings revealed an independent association of lower BMD, in particular sub-regions of legs, with higher CAC score, in females but not in males. ESRD patients at increased risk for high CAC score could potentially be detected by low BMD.