Dietary pattern specific protein biomarkers for cardiovascular disease: A cross-sectional study in 2 independent cohorts
Journal of the American Heart Association Jun 07, 2019
Lemming EW, et al. - Given a lack of full understanding of mechanisms associated with the impact of diet on the development of cardiovascular disease and a possible utility of protein biomarkers to help understand these pathways, researchers focused on biomarkers recognized with multiplex proteomic methods and dietary patterns in this study using 2 population-based Swedish cohorts, the EpiHealth study with 20,817 men and women and the Swedish Mammography Cohort Clinical (SMCC) with 4,650 women. They discovered four main dietary patterns in the EpiHealth and three in the SMCC. Both cohorts demonstrated “healthy” and “Western/traditional” patterns. The independent links between dietary patterns and 21 biomarkers related to cardiovascular disease were identified and replicated in this study, with a role suggested for these biomarkers in the pathways associated with inflammation, endothelial and immune function, cell adhesion, and metabolism.
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